Dr. Jeong-Ho Kim

Associate Professor of Biology

(434) 582-2462
jkim172@liberty.edu
Center for Natural Sciences, Room 150

Education

• Postdoctoral Research in Molecular & Cellular Biology, Washington University School of Medicine
• Ph.D. in Microbial Molecular Genetics, University of Wisconsin-Madison
• B.S., Chonnam National University

Biography

Dr. Kim obtained his Ph.D. in microbial molecular genetics from the University of Wisconsin (Madison, WI) and did postdoctoral research in molecular and cellular biology at Washington University School of Medicine (St. Louis, MO). He was a faculty member at the University of Southern Mississippi and an Assistant Science Advisor to the NIH-sponsored MS-INBRE (Hattiesburg, MS). He joined Liberty after teaching at the George Washington University School of Medicine and Health Sciences (Washington, DC).

Research

Dr. Kim’s research interests are largely directed toward understanding how environmental cues interact with genetic components to regulate cell growth and development.  He is particularly interested in learning how nutrients and metabolites transduce information to cellular effector functions and how dysregulation of this process leads to metabolic diseases, such as obesity, type 2 diabetes, and cancer.

Courses Taught

• Genetics (BIOL 301)
• Genetics Lab (BIOL 301L)

Publications

Nutrient sensing and metabolite signaling in yeast as a model system

• Adhiraj Roy, Salman Hashmi, Zerui Li, Angela D. Dement, Kyu Hong Cho, and Jeong-Ho Kim. 2016. The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast. Mol. Biol. Cell. 27:862-871.
• Adhiraj Roy, Angela D. Dement, Kyu Hong Cho, and Jeong-Ho Kim. 2015. Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1).  PLoS ONE 10(3):e0121985.
• Adhiraj Roy, Yong-Bae Kim, Kyu Hong Cho, and Jeong-Ho Kim. 2014.  Glucose starvation-induced turnover of the yeast glucose transporter Hxt1. Biochim. Biophys. Acta 1840:2878-2885.
• Adhiraj Roy, David Jouandot II, Kyu Hong Cho, and Jeong-Ho Kim. 2014. Understanding the mechanism of glucose-induced relief of Rgt1-mediated repression in yeast. FEBS Open Bio. 4:105-111.
• Jeong-Ho Kim, Adhiraj Roy, and Kyu Hong Cho. 2013. The glucose signaling network in yeast (review). Biochim. Biophys. Acta.  1830:5204-5210.
• Adhiraj Roy, Yong Jae Shin, Kyu Hong Cho, and Jeong-Ho Kim. 2013. Mth1 regulates the interaction between the Rgt1 repressor and the Ssn6-Tup1 corepressor complex by modulating PKA-dependent phosphorylation of Rgt1.  Mol. Biol. Cell. 24:1493-1503.
• Adhiraj Roy, Yong Jae Shin, and Jeong-Ho Kim. 2013. Construction of yeast strains useful for screening drugs that inhibit glucose uptake and glycolysis.  Anal. Biochem. 436:53-54.
• David JouandotII, Adhiraj Roy and Jeong-Ho Kim. 2011. Functional dissection of the glucose signaling pathways that regulate the yeast glucose transporter gene (HXT) repressor Rgt1. J Cell. Biochem. 112:3268-3275.
• Satish Pasula, Samujjwal Chakraborty, Jae Ho Choi, and Jeong-Ho Kim. 2010. Role of casein kinase 1 in the glucose sensor-mediated signaling pathway in yeast. BMC Cell Biol. 11:17-26.
• Jeong-Ho Kim. 2009. DNA-binding properties of the yeast Rgt1 repressor. Biochimie 91:300-303.
• Satish Pasula, David JouandotII, and Jeong-Ho Kim. 2007.  Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae. FEBS letter. 581:3230-3234.
• Jeong-Ho Kim and Mark Johnston. 2006. Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in S. cerevisiae. J. Biol. Chem. 281: 26144-26149.

Development and progression of prostate cancer in a mouse model

• Yong-Bae Kim, Yong Jae Shin, Adhiraj Roy, and Jeong-Ho Kim. 2015. The role of the pleckstrin homology domain-containing protein CKIP-1 in activation of p21-activated kinase 1 (PAK1). J. Biol. Chem. 290:21076-21085.
• Yong Jae Shin, Yong-Bae Kim, and Jeong-Ho Kim. 2013. Protein kinase CK2 phosphorylates and activates p21-activated kinase 1 (PAK1). Mol. Biol. Cell. 24:2990-2999.
• Yong Jae Shin, Eun Hye Kim, Adhiraj Roy, and Jeong-Ho Kim. 2013. Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. PLoS ONE 8:e71494.
• Yong Jae Shin and Jeong-Ho Kim. 2012. The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells. PLoS ONE 7:e30393.

Bacterial pathogenesis: Molecular analysis of the virulence factors of Streptococcus pyogenes

(Collaborative research)

• Leslie Brown, Jeong-Ho Kim, and Kyu Hong Cho. 2016. Presence of a prophage determines temperature-dependent capsule production in Streptococcus pyogenes. Genes (Basel) 7:74.
• Kyu Hong Cho and Jeong-Ho Kim. 2015. Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. Front. Genet. 6:1-10.
• Rafael A. Tesorero, Ning Yu, Jordan O. Wright, Juan P. Svencioni, Qiang Cheng, Jeong-Ho Kim, and Kyu Hong Cho. 2013. Novel Regulatory Small RNAs in Streptococcus pyogenes. PLoS ONE 8:e64021.
• Kyu Hong Cho, Jordan O. Wright, Juan P. Svencioni, Qiang Cheng and Jeong-Ho Kim. 2013. The prince and the pauper: Which one is real? The problem of secondary mutation during mutagenesis in Streptococcus pyogenes. Virulence 4:1-2.

Glucose signal transduction in yeast

• Jeong-Ho Kim, Valerie Brachet, Hisao Moriya and Mark Johnston. 2006. Integration of transcriptional and posttranslational regulation in a glucose signal transduction pathway in Saccharomyces cerevisiae.  Eucaryot. Cell 5:167-173.
• Mark Johnston and Jeong-Ho Kim. 2005. Glucose as a hormone: receptor-mediated glucose sensing in the yeast S. cerevisiae. Biochem. Soc.Trans. 33:247-252.
• Jeff Polish, Jeong-Ho Kim, and Mark Johnston. 2005. How the Rgt1 transcription factor of S. cerevisiae is regulated by glucose. Genetics 169:583-594.
• Jeong-Ho Kim. 2004. Immobilized DNA-binding assay, an approach for in vitro DNA-binding assay. Anal. Biochem. 334:401-402.
• Aneta Kaniak, Zhixiong Xue, Daniel Macool, Jeong-Ho Kim and Mark Johnston. 2004. A regulatory network connecting two glucose signal transduction pathways in Saccharomyces cerevisiae.  Eucaryot. Cell 3:221-231.
• Jeong-Ho Kim, Jeff Polish, and M. Johnston. 2003. Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Mol. Cell. Biol. 23:5208-5216.

Carbon catabolite repression in bacteria

• Jeong-Ho Kim, Young Ki Yang, and Glenn H. Chambliss. 2005. Evidence that Bacillus catabolite control protein CcpA interacts with RNA polymerase to inhibit transcription of catabolite repressible genes. Mol. Microbiol. 56:155-162.
• Jeong-Ho Kim, Martin I. Voskuil, and Glenn H. Chambliss. 1998. NADP(H), corepressor for the Bacillus catabolite control protein CcpA. Proc. Natl. Acad. Sci. USA 95:9590-9595.
• Andrew J. Turinsky, Frank J. Grundy, Jeong-Ho Kim, Glenn H. Chambliss, and Tina M. Henkin. 1998. Transcriptional activation of the Bacillus subtilis ackA gene requires sequences upstream of the promoter. J. Bacteriol. 180:5961-5967.
• Jeong-Ho Kim and Glenn H. Chambliss. 1997. Contact between Bacillus subtilis catabolite regulatory protein CcpA and amyO target site. Nucleic Acids Res. 25:3490-3496.
• Jeong-Ho Kim, Zehra T. Guvener, Jae Yong Cho, Ki Chul Chung, and Glenn H. Chambliss. 1995. Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA. J. Bacteriol. 177:5129-5134.

Biotechnology: Bioconversion of renewable resources into useful chemicals and fuels

• Jeong-Ho Kim, J. C. Lee, Y. K. Lee, K. W. Kim, S. B. Chun, and K. C. Chung. 1993. Purification and Characterization of Carboxymethyl Cellulase IV from Penicillium verruculosum. Kor. J. Mycology 21:28-37.
• Jeong-Ho Kim, J. W. Huh, H. J. Chung, Y. K. Lee, and K. C. Chung. 1992. Formation and regeneration of conidial protoplast from penicillium verruculosum. Kor. J. Microbiol. 30:154-159.
• Jeong-Ho Kim, K. C. Chung, H. S. Kang, and Y. K. Lee 1991. Purification and in vitro translation of penicillium verruculosum cellulase mRNA. J. Microbiol. Biotech.1:232-239.
• Jeong-Ho Kim, J. C. Lee, J. H. Huh., K. C. Chung, Y. J. Baek, and Y. K. Lee. 1991. Molecular cloning of beta-galactosidase gene from Bacillus subtilis HP-4. J. Microbiol. Biotech. 1: 227-231.