Office: Micro/Molecular Hall (Dorm 13) 204
Dr. Michael Price grew up in New Castle, Delaware and attended college at the University of Delaware (Go Blue Hens!), where he earned a B.S. degree in Animal Science. He married his college sweetheart right before moving to North Carolina to study Plant Pathology at NC State University, where he earned both M.S. and Ph.D. degrees. In graduate school, Dr. Price studied biomediation using filamentous molds, as well as the genetic regulation of the production of the most potent naturally occurring carcinogen, aflatoxin, in Aspergillus species.
After graduating from NCSU in 2005, he joined the Duke University Mycology Research Unit at Duke Medical Center to investigate the genetic basis of pathogenicity in the Cryptococcus/human pathosystem. First, he worked with Andrew Alspaugh on the involvement of the GTPase regulatory protein in Rdi1 in cryptococcal pathogenesis. Following publication of that work, he joined the lab of John Perfect to investigate carbon and nitrogen acquisition from the host by pathogenic Cryptococcus species. His current research continues these projects in understanding how pathogens acquire nutrients from their hosts.
1. Inoue M, Arikawa T, Chen Y-H, Moriwaki Y, Price M, Brown M, et al. T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. Proceedings of the National Academy of Sciences. 2014:201321427. doi:10.1073/pnas.1321427111.
2. Frazzitta, AE, H Vora, MS Price, JL Tenor, M Betancourt-Quiroz, DL Toffaleti, N Cheng, and JR Perfect. 2013. Nitrogen source-dependent capsule induction in human pathogenic Cryptococcus species. Eukaryotic Cell 12(11):1439-1450.
3. Tseng, H.-K., C-P Liu, MS Price, AY Jong, J-C Chang, DL Toffaletti, M Betancourt-Quiroz, AE Frazzitta, W-L Chow, and JR Perfect. 2012. Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System. PLoS One, 7(9), e45083. doi:10.1371/journal.pone.0045083.
4. Fang, W, MS Price, DL Toffaletti, J Tenor, M Betancourt-Quiroz, JL Price, W-H Pan, W-Q Liao, JR Perfect. 2012. Pleiotripic effects of deubiquitinating enzyme Ubp5 on growth and pathogensis of Cryptococcus neoformans. PLoS One, 7(6), e38326. doi:10.1371/journal.pone.0038326.
5. Price, MS, M Betancourt-Quiroz, JL Price, DL Toffaletti, H Vora, G Hu, JW Kronstad, and JR Perfect. 2011. Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. mBio 2:e00111.
6. Lee, A DL Toffaletti, J Tenor, EJ Soderblom, JW Thompson, MA Moseley, MS Price, and JR Perfect. 2010. Survival defects of Cryptococcus neoformans mutants in human cerebrospinal fluid results in attenuated virulence in an experimental model of meningitis. Infection and Immunity 78:4213-4225.
7. O'Meara, TR, C Hay, MS Price, S Giles, and JA Alspaugh. 2010. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryotic Cell 9:1193-1202.
8. O'Meara, TR, D Norton, MS Price, C Hay, MF Clements, CB Nichols, and JA Alspaugh. 2010. Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. PLoS Pathogens 6:e1000776.
9. Price, MS, CB Nichols, and JA Alspaugh. 2008. Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infection and Immunity 76(12):5729-5737.
10. He, ZM, MS Price, GR OBrian, DR Georgianna, and GA Payne. 2007. Improved protocols for funtional analysis in the pathogenic fungus. Aspergillus flavus. BMC Microbiology 7:104.
11. Cramer, KL, QD Gerrald, CB Nichols, MS Price, and JA Alspaugh. 2006. Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. Eukaryotic Cell 5:1147-1156.
12. Price, MS, J Yu, WC Nierman, HS Kim, B Pritchard, CA Jacobus, D Bhatnagar, TE Cleveland, and GA Payne. 2006. The aflatoxin pathway regulator AflR introduces gene transcription inside and outside of the aflatoxin biosynthetic cluster. FEMS Microbiology Letters 255:275-279.
13. Price, MS, SB Conners, S Tachdijian, RM Kelly, and GA Payne. 2005. Alatoxin conducive and non-conducive growth conditions reveal new gene associations with aflatoxin production. Fungal Genetics and Biology 42:506-518.
14. Price, MS, JJ Classen and GA Payne, 2000. Aspergillus niger removes copper and zinc from swine wastewater. Bioresource Technology. 77(1):41-49.