Student and Faculty Research
LUCOM hosted its third Research Day on Jan. 7, 2022. After the impact of COVID-19 and the near-conclusion of virtual research conferences, LUCOM Research Day highlights the work of numerous LUCOM faculty and student-doctors, as well as residents and attending physicians from some of our clinical affiliates.
Featured below are detailed lists that showcase LUCOM research and scholarly activity of Liberty University osteopathic medical students and faculty, as well as undergraduate students.
LUCOM faculty are in bold font.
Active Research and Scholarly Activity Programs by LUCOM Faculty
Anthony Bauer, PhD
- Inflammation and GI tract dysfunction
- Post-operative ileus and Shigellosis using mouse models
- Conceptual design, construction, and implementation of a microscopic live color imaging system to record the regulation of the colonic microvasculature
Joseph Gigliotti, PhD
- Determining the effect of diet and exercise on liver and kidney health in mice
- Determining the effect of diet and probiotic administration on gut microbiome and metabolic health
- Determining the influence of steroid intermediates on the function of renal proximal tubule cells
- Assessing healthcare provider attitude and approach to managing ankyloglossia in pediatric population
Charles Joseph, MD
- Integrated osteopathic-neurologic examinations with musculoskeletal treatment
- A new comprehensive Liberty Osteopathic Manipulative Medicine treatment tool
- Utilizing timed categorical recall (naming US cities) for rapid bedside dementia screening
- Using 3D ASL MRI to identify reduced glymphatic outflow in preclinical dementia
- Post–concussive head injury: Is disturbance of Glymphatic flow both an indicator of injury and with normalization correlated with recovery?
Laurieanne Hemric, PhD
- Anatomical study of abdominal arterial tree
- Anatomical study of the upper extremity
- Anatomical study of the lower extremity and oronasal fistula
- Anatomical study of the abdominal cavity
- Anatomical study of the female pelvic cavity and perineum
Carl Hoegerl, DO
- Clinical scholarly writing and neurological disorders
- Case reports and review articles
Yingguang Liu, PhD
- Effect of Dolutegravir on breast cancer development
- Effect of Decitabine on breast cancer development
- Effect of MiR198 on cancer growth
John R. Martin, PhD
- Characterization of serotonin receptor subtype in anterior hypothalamic/preoptic area of rat involved in cardiovascular response to the serotonin agonist DOI
Linda Mintle, PhD
- The impacts of the COVID-19 pandemic on medical students in the 2021-2022 NRMP application process
- Skills to build resiliency in medical students.
- Assessing harm reduction acceptance and spirituality in preclinical medical students
- Integrating cultural sensitivity into a skills-based approach of delivering bad news
- The effect of forgiveness and service love intervention on psychological well-being for COM students
- Assessing stress-related eating habits of medical students during COVID 19
Michael Price, PhD
- Gene regulation of pathogenicity in the human pathogenic yeast Cryptococcus neoformans
Scott Severance, PhD
- Ethics and the healthcare team: educating to build moral resilience
- Insight into student habits and practices during medical school remediation
- Learning to thrive: learning strategies for medical school and beyond
- Tracking sleep and measuring the influence of sleep information on the sleep habits of first-year medical school students
- Determining efficacy of experiential learning activities on skill acquisition and overall well-being among OMS II students
R. James Swanson, PhD
- Mouse embryo development in the presence of condensed vapor with varying levels of nicotine and flavor
Extramural Research Grants Awarded
2018-19
Gigliotti, J.C. Renal mechanisms of blood pressure regulation and salt-sensitivity by collectrin. National Institutes of Health.
2019-20
Bauer, A.J. Exploration of the therapeutic potential of DNA-based immunomodulatory sequences for gastrointestinal inflammatory diseases. Index Pharmaceuticals.
Gigliotti, J.C. Determining the effect of biological sex and therapy on diet-induced alterations in liver and kidney health in mice. American Osteopathic Association.
2021-22
Liu, Y. Effect of aerosolization using a vibrating mesh micropump on the effect of ribavirin against respiratory syncytial virus. Aerogen, LTD.
Peer-Reviewed Publications
2018-19
Bauer, A. J. Ileocecal anastomosis type significantly influences long-term functional status, quality of life, and healthcare utilization in postoperative Crohn’s disease patients independent of inflammation recurrence
Gigliotti, J.C. Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction
Gigliotti, J.C. Potential health benefits and safety of apple pomace for human consumption
Jasperse J.L. Arteriolar vasodilation involves actin depolymerization
Liu, Y. DNA barcodes show gaps between species and support recent common bottleneck
Liu, Y. Expression of human endogenous retroviruses in peripheral leukocytes during the menstrual cycle suggests coordinated hormonal regulation
Mintle, L. Opioid abuse and dependence: Update in neuroscience and treatment
Mintle, L. Pain Management: What the latest research tells us
Mintle, L. Strategies for family conflict
Pettitt, R.M. Newborn Disorders and Nutritional Guidance
Severance, S. Corroboration of Zn(II)–Mg(II)-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme
2019-20
Gigliotti, J.C. GSTM1 deletion exaggerates oxidative stress and kidney injury in experimental mouse models and modifies the protective effect of cruciferous vegetables against kidney disease in mice and humans.
Gigliotti, J.C. Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury.
Liu, Y. Female sex hormones activate human endogenous retrovirus type k through the OCT4 transcription factor in T47D breast cancer cells
Mintle, L. Binge TV viewing on mobile devices
Mintle, L.S. A longitudinal assessment of medical student emotional intelligence (EI) over the first two years of medical training
Mintle, L.S. and Kribs, J. Living Beyond Pain
Pettitt, R.M. Skin & soft tissue infections: it’s more than just MRSA
2020-21
Gigliotti, J.C. T-cell derived extracellular vesicles are elevated in essential hypertension
Gigliotti, J.C. Collectrin (Tmem27) deficiency in the proximal tubule causes hypertension and Tmem27 single nucleotide polymorphisms associate with diastolic blood pressure in males in meta-analysis of two community studies
Joseph, C.R. Utilizing timed categorical recall (naming U.S. cities) for rapid bedside dementia screening
Joseph, C.R. Integrated Osteopathic-Neurologic Exams with Musculoskeletal Treatment: The ONE Approach
Joseph, C.R. Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects
2021-22
Liu, Y. Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity
Liu, Y. Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K
Phipps, S. Supplemental instruction in pharmacy education: Lessons learned from collected perceptions
Severance, S. Sensitive Assay for the Lactonase Activity of Serum Paraoxonase 1 (PON1) by Harnessing the Fluorescence Turn-On Characteristics of Bioorthogonally Synthesized and Geometrically Controlled Chemical Probes
Severance, S. Time-dependent effects of storage at -80 °C on the stability of butyrylcholinesterase activity in human serum
Published Case Reports, Literature Reviews, and Book Chapters
2019-20
Behnke, A. Severe Hyponatremia Following Rhabdomyolysis and Acute Renal Failure in a Young Patient with Undiagnosed Hypothyroidism.
Gigliotti, J.C. Mechanisms and pathophysiology of hypertension.
Lockwood, M. The Heart and Hands of an Osteopathic Physician.
Lockwood, M. Proprioceptive Coherence an Expanded View of the Mechanics behind the Indirect Method and the Introduction of an Innovative Variation.
Lockwood, M. Case History Three: “Mitch” and his Helicopter Cross-Control Fascial Strain.
Lockwood, M. Case History One: Low back and hip pain with arthritis.
Lockwood, M. Case History Two: Low back and hip pain with arthritis.
Mintle, L. The do’s and don’ts of marital separation.
Mintle, L. Living beyond pain.
2020-21
Hoegerl, C. A Case of Meige Syndrome Treated with Baclofen.
Joseph, C.R. A review of fluid flow in and around the brain, modeling, and abnormalities.
Liu, Y. Practical Exercises in in Microbiology, 3rd ed.
Mintle, L. Deconversion: Are We Blaming the Victim?
Mintle, L. Answering the Call to Christian Counseling?
2021-22
Gigliotti, J.C. Mouse models of acute kidney injury.
Hoegerl, C. Review of Sudden Sensorineural Hearing Loss.
Joseph, C.R. Basics of Fluid, Electrolyte and Acid-Base Disturbances: Treatment Guidelines for Medical Students and Residents.
Leonard, T.O. A case report of scrotal lipoma and review of lipoma pathogenesis.
Liu, Y. Immune Aberrations in Tumor Microenvironment.
Liu, Y. Degeneration of SARS-CoV-2.
Pettitt, R. An Osteopathic Approach to Anemia.
Price, M. Influence of pathogen carbon metabolism on interactions with host immunity.
Research and Scholarly Presentations
2018-19
Boyer, M.E., and Creighton, S. Advancing ultrasound techniques in Guatemala
Brewer, J.W. The unfolded protein response, microRNA-214, and expression of the transcription factor XBP1.
Cook, J., Bogacz, K., and McLario, D. Medical students as point-of-care ultrasound instructors: learners as successful teachers
Gigliotti, J.C. Determining the effect of a novel disease-inducing rodent diet on outcomes of a murine model of polymicrobial sepsis
Gigliotti, J.C. Determining the influence of a novel Americanized rodent diet on renal health in wild-type mice administered angiotensin II
Gigliotti, J.C. Determining the influence of a novel rodent diet on body weight gain and renal health in male mice from 2 different strains
Gigliotti, J.C. Determining the significance of a novel disease inducing rodent diet on adenocarcinoma growth in vivo
Gigliotti, J.C. Neutrophil depletion influences renal outcomes in male mice with chronic angiotensin II infusion
Jasperse, J.L. Nitric oxide and sympatholysis in rat soleus feed arteries
Liu, Y. Integrated Regulation of Class II Human Endogenous Retroviruses in a Breast Cancer Cell Line
Liu, Y. Synergistic activation of LTR5HS by progesterone and the OCT4 transcription factor
Mintle, L. CME-Motivational Interviewing
Mintle, L. Preconference workshop: Chronic Pain with Michael Lyles, MD and Workshop: The Neuroscience of Addiction Relapse
Patterson, E. The History of Virginia’s Medical Futility Legislation
Swanson R.J. Nanosecond Pulsed Electric Field (nsPEF) causes Instantaneous Cellular Membrane Modulation by altering Calreticulin Expression
Swanson R.J. Design in Biology
Swanson R.J. Nanosecond Pulsed Electric Fields (nsPEFs) cause Neuromuscular Disruption in Rats
Swanson, R.J. Intermittent hypoxia remedies male subfertility in humans
Troy, A. E. Evaluation of lecture presentation style in anatomical medical education
2019-20
Bauer, A.J. Colitis Induced Microvascular Leak Triggers a Neurogenic Disruption in Gastrointestinal Motility
Bauer, A.J. Exogenous synthetic oligonucleotide-based immunomodulatory agonists ameliorate postoperative ileus
Bauer, A.J. Peripheral Tissue Injury and Acute Pancreatitis Cause a SIRS-induced Intestinal Microvascular Leak Triggering Ileus via a Specific Enteric Leak Factor (ELF)
Bauer, A.J. Peripheral tissue injury and endotoxin induce a systemic inflammatory response with perfuse intestinal microvascular leak that triggers a neurogenic disruption in gastrointestinal motility
Bauer, A.J. Synthetic Tlr9 Agonists Modulate Postoperative Ileus
Bauer, A.J. Thermal ultrasound induction of an abdominal heat-shock response prevents postoperative ileus
Bauer, A.J. TLR4/MyD88 Signaling Pathway Mediates Peripheral Tissue Injury Induced Gastrointestinal Ileus and Systemic Inflammation
Bauer, A.J. Vero Cell Decoy Membrane Receptors as a Novel Biopharmaceutical Treatment for Shiga Toxin Producing Bacteria
Bauer, A.J. Crohn’s Disease: Research Advances in Etiology, Treatment and Surgical Outcomes
Behnke, A. J. Differences in the diet of central Virginia counties with different rates of diabetes
Behnke, A. J. Hypercalcemia from orange juice- an unusual presentation of the milk alkali syndrome
Behnke, A. Medical error recognition by medical students during simulated asystole: teamwork and assertiveness from aviation
Brewer, J. Regulation of MicroRNA-214 expression in the mammalian unfolded protein response
Cole, S. Infant safe sleep and the VDSS Baby Box Program: Implementation at a community-based hospital
Gigliotti, J.C. Determining the Physiological, Immunological, and Metabolic Consequences of Chronic Angiotensin II Infusion in Mice
Gigliotti, J.C. Diet significantly influences the physiological and metabolic outcomes of the angiotensin II mouse model of cardiorenal injury
Gigliotti, J.C. Pulsed Ultrasound Attenuates the Hyperglycemic Exacerbation of Myocardial Ischemia-Reperfusion Injury through Vagus Nerve and Acetylcholine Signaling
Gigliotti, J.C. Anesthetic influences outcomes of the chronic angiotensin II infusion model in mice
Gigliotti, J.C. Determining the effect of diet on a novel model of fecal peritonitis in mice
Gigliotti, J.C. Determining the effect of diet on liver and renal health in a mouse model of chronic alcohol intake
Gigliotti, J.C. Determining the effect of diet on renal health and function in 2 strains of mice
Gigliotti, J.C. Determining the effect of diet on weight gain and metabolic dysfunction in 2 strains of mice
Gigliotti, J.C. Determining the physiological interaction between diet and alcohol intake in male mice
Gigliotti, J.C. Re-characterizing the murine chronic angiotensin II model of cardiovascular and renal injury
Hoegerl, C. Movement Disorders
Hoegerl, C. A case of a cervical pannus without rheumatoid arthritis or trauma
Joseph, C. R. Assessing prevalence of validated risk factors in Alzheimer disease: Toward developing a risk scale
Joseph, C.R. Novel method utilizing arterial spin labeling single acquisition 3d echo planar imaging for determining CNS waste clearance by the glymphatic/vascular systems
Joseph, C.R. Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects
Joseph, C.R. Rapid clinical screening test for dementia
Kribs, J.W., Toler, A., Mintle, L.S., and Dyson, A. Integrating pain management competencies into the osteopathic medical school curriculum
Liu, Y. The effect of anti-retroviral drugs on HERV protein expression in cancerous and non-cancerous cells.
Mintle, L. Motivational Interviewing
Potter, L. Patient rationale behind the refusal of hospital transportation
Schuller, C. Adverse Outcomes in Patients with Asymptomatic Subchorionic Hematomas
Schuller, C. Growing the Next Generation of Processionals: Utilizing Obstetric Simulation in the Women’s Health Course as a Foundation for Inter-Professional Education and Collaboration
Selwyn, J. Rapidly growing left atrial myxoma with patent foramen ovale, and left-to-right shunt presenting with dyspnea
Severance, S. Toward a better understanding of non-academic factors
Severance, S. McGlauflin, J., and Ojuola, O. Identifying unspoken differences and goals in medical school to enhance student learning
Severance, S. McGlauflin, J., and Jones, J. Learning to thrive: learning strategies for medical school and beyond
Swanson, R.J. Vaping condensate intraperitoneal exposure to in vitro mouse embryos
2020-21
Bauer, A.J. Nitrated-Oleic Acid Amelioration of Dextran-Sodium Sulfate Induced Colitis
Bauer, A.J. Nitrated-Oleic Acid and IDX 9059 in Amelioration of Postoperative Ileus
Bauer, A.J. Peripheral Tissue Injury: The role of TLR in trauma associated gastrointestinal ileus in SIRS
Brands, C. Implementing the Migraine Disability Assessment (MIDAS) Tool to Continuously Improve Systems-Based Care Provided to Patients with Migraine in a Resident-Faculty Practice
Gigliotti, J.C. Determining the Effect of IL233 in Established Angiotensin II-Induced Hypertension in the 129SVEV Mouse
Gigliotti, J.C. Determining the Effect of Prophylactic IL-233 Administration on Angiotensin II-Induced Hypertension in the C57BL/6 Mouse Strain
Gigliotti, J.C. Determining the Physiological, Immunological, and Metabolic Consequences of Chronic Angiotensin II Infusion in Mice
Gigliotti, J.C. Diet Significantly Influences Physiological and Metabolic Outcomes of a Mouse Model of Cardiovascular Disease
Gigliotti, J.C. Interleukin-6, leptin, and adiponectin expression in mouse adipose tissues is influenced by diet and angiotensin II infusion
Gigliotti, J.C. Investigating the Prophylactic and Therapeutic Effect of IL233 Administration on Angiotensin II-Induced Hypertension in 129SVEV and C57BL/6 Mouse Strains
Gigliotti, J.C. Prophylactic Administration of IL233 in Angiotensin II-Induced Hypertension in the 129SVEV Mice Strain
Hemric, M. Lifebook Excerpt: Assessing Health from Home
Joseph, C.R. Osteopathic Manipulation Improves Patient Pain Scale Regardless of Operator Experience
Lee, C. Impact of a pandemic on nursing students: does faith influence
Lee, C. Measurement Invariance Test of BGRI Between Black and White Women
Liu, Y. Antiretroviral agent inhibits proliferation and motility of BT-20 cells through inhibition of human endogenous retrovirus type K
Liu, Y. Over-expression of HERV-K Genes Enhances the Resistance of MCF12A Cells against Efavirenz.
Lockwood, M. The “ONE” Approach: An Integrated Osteopathic-Neurological Examination Enhancing Patient Care
Maitland, L. Overcoming Challenges in Web-side Teaching: Lessons Learned in Medical Student Telehealth Education
Miller, E. Effect of Osteopathic Manipulative Treatment in the Management of Refractory Postoperative Ileus Following Major Abdominal Surgery
Mintle, L. Religiosity as a protective factor in psychological well-being of medical Students: A one-year analysis
Mintle, L. The Association Between Religiosity and Psychological Well-Being: A One-year Analysis
Ojuola, O. Breastfeeding and Ankyloglossia – A Review of its Definition, Diagnosis, and Treatment across specialties
Pettitt, R. The Impact of Climate Change on our Patients’ Health and the Family Physician Role
Price, M. Developing a BSL1 titan cell model for cell cycle studies
Price, M. Effects on Virulence of Cryptococcus neoformans via Deletion of Hypothesized pH Response Genes
Price, M. Extent of Titan Cell Formation in the Cryptococcoses
Price, M. Investigating the link between pH regulation and membrane trafficking in Cryptococcus neoformans
Price, M. Investigation of the Genetic Basis for Cryptococcus neoformans adaptation to the pH of Host Environment
Price, M. pH Response Genes in Cryptococcus neoformans
Price, M. The evaluation of interactions between mouse bone marrow macrophages and the MPC31 strain of the pyk1Δ mutant strain of Cryptococcus neoformans via phagocytosis assay
Schuller, C. Does the use of earplug-aided tocodynamometers improve labor outcomes?
Schuller, C. The Efficacy of The Motherhood Collective Labor Comfort Measures Workshop
Severance, S. Identifying and Monitoring Changes in the Study Habits of First-Year Medical School Students
Severance, S. Learning to Thrive: Learning Strategies for Medical School and Beyond
Severance, S. Seeking an Understanding of What Makes Successful Students Successful
Severance, S. The Effect of Sleep & Sleep Training on Wellness and Performance of Medical School Students
Swanson, R.J. Two-Cell-To-Hatching-Blastocyst Development of Mouse Embryos During Continuous Culture with Electronic Cigarette (E-Cig) Aerosol Condensate
2021-22
Bauer, A.J. Acute Mechanisms of Sterile Tissue Injury Induced Vascular Leak, Ileus and Death
Bauer, A.J. 3D Architecture of the Intestinal Microvasculature and Its Association with the Enteric Nervous System and Innate Immune Cells
Bauer, A.J. Acute Endothelial Cell Dysfunction Caused By A Protein Extract From Damaged Skeletal Muscle
Bauer, A.J. Architecture of the Intestinal Microvasculature and Its Association to the Enteric Nervous System and Immune Cell Populations
Bauer, A.J. Conceptual Design, Construction, and Implementation of a Microscopic Live Color Imaging System to Record the Regulation of the Colonic Microvasculature
Bauer, A.J. Development of a Model of Postoperative Surgical Adhesions and Potential Pharmacological Preventions
Bauer, A.J. Elucidation of A Novel Mechanism Of Perioperative And Postoperative Ileus: Microvascular Leak Of Serum Immunoglobulins Directly Activate Inhibitory Nitrergic Neuromuscular Transmission Causing Ileus
Bauer, A.J. Iatrogenic-induced Intestinal Microvascular Leak as a Novel Mechanism of Perioperative Ileus
Bauer, A.J. Intestinal Microvascular Leak as the Major Cause of Perioperative Ileus
Bauer, A.J. Isolation and Physiological Effects of an Intestinal Serum Enteric Leak Factor on the Murine Colonic Circular and Longitudinal Muscle Contractility
Bauer, A.J. Isolation, Characterization and Effects of a Novel Peripheral Tissue Injury Extract Causing Endothelial Cell Dysfunction, Ileus and a Precipitous Death
Bauer, A.J. Therapeutic Potential of miR-198 to Suppress MC38 Colonic Adenocarcinoma
Bauer, A.J. Therapeutic Potential of Synthetic Oligonucleotide Immunomodulatory Agonists to Ameliorate Postoperative Ileus
Gigliotti, J.C. Characterizing the Effect of Different Diets on The Structure Of The Liver And Kidney In Male C57BL/6 Mice
Gigliotti, J.C. Determining the Effect of Biological Sex and Therapy On Diet-Induced Alterations In Liver And Kidney Health In Mice
Gigliotti, J.C. Determining the Effect of Diet on Markers of Lipid Metabolism in a Mouse Model of Hypertension.
Hemric, M. “Lifebook
Hoegerl, C. Sudden Hearing Loss and Why It’s an Emergency!
Hoegerl, C. What’s new in Neurology 2021?
Jasperse, J. Applying Bloom’s Taxonomy in Medical Education
Jasperse, J. Inhibition of Endothelium-Dependent Hyperpolarization Attenuates Reactive Dilation in Isolated Rat Soleus Feed Arteries
Jasperse, J. The Role of Membrane Hyperpolarization and SKCa and IKCa Potassium Channels In Nitric Oxide Mediated Inhibition of Functional Sympatholysis
Lee, C. Hybrid Threshold-Sequential Procedures for the CAT Security.
Leonard, T.O. Gallbladder Malakoplakia
Liu, Y. Decitabine inhibits breast cancer cell proliferation through inhibition of endogenous retroviruses in vitro.
Liu, Y. Multiyear Changes in the Genome of SARS-CoV-2 Reveal a Trend of Degeneration
Maitland, L.A. & Mintle, L. Multidisciplinary Case Approach for Primary Care, Dermatology and Psychiatry Through the Development of a Self-Learning Module
Mintle, L. Analysis of Presurvey Data for A Forgiveness And Agape Love Intervention
Mintle, L. Empowering a student-led grassroots movement to increase DEI awareness and actions among DO medical students and faculty
Ojuola, O., & Gigliotti, J.C. Ankyloglossia: Definition, Diagnosis, And Treatment
Pelletier, M. ExamSoft Categories and Machine Learning to Identify Students at High Risk of Failing Board Exams
Price, M. Characterization of a putative histone acetyltransferase in Cryptococcus neoformans
Price, M. Deletion of pH Response Genes in Cryptococcus neoformans
Price, M. Influence of pathogen carbon metabolism on interactions with host immunity. Frontiers in Cellular and Infection Microbiology
Price, M. Investigating the link between pH Regulation and membrane trafficking in Cryptococcus neoformans