Charles R. Joseph, MD

Associate Professor of Neurology, Clerkship Director


  • MD, Temple University
  • BA, University of Virginia
  • Board certified Neurologist – American board of Neurology and Psychiatry
  • Board certified – United Council for Neurologic subspecialties – Neuroimaging

Courses Taught

  • Geriatrics & End of Life – GERI
  • Hematology/Oncology – HO
  • Internal Medicine II
  • Nephrology
  • Neurology
  • Osteopathic Manipulative Medicine – OMM
  • Patient-Centered Medicine – PCM
  • Population-Based Medicine – PBM
  • Pulmonary
  • Urinary System – URI

Professional Memberships

  • American Academy of Neurology (AAN)
  • Lynchburg Academy of Medicine (LAM)
  • Medical Staff, Lynchburg General Hospital
  • Virginia Neurologic Society (VNS)


Dr. Joseph attended Temple University medical school in Philadelphia, followed by two years of internal medicine residency and three years of Neurology residency both at the University of Virginia. He practiced general neurology, neurophysiology, and neuroimaging with Neurology Associates of Lynchburg for 32 years before joining the faculty at LUCOM.

At LUCOM, his primary efforts are teaching Neurology, Nephrology, and physical diagnosis in addition to caring for patients in the Free Clinic. Clinical research interests include validation of physical exam techniques, developing a better approach to chronic pain management utilizing less reliance on pharmacologic measures, and early clinical aspects of neurodegenerative disease presentations.

Research Interests

  • Development of novel methods of quantitating benefits of osteopathic manipulation
  • Evaluation of clinical methods for evaluating long term memory
  • Investigation of glymphatic flow using MRI technology in CNS disease


  • Joseph, C. R., Benhatzel, C. M., Stern, L. J., Hopper, O. M., & Lockwood, M. D. (2020). Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects. Magnetic Resonance Materials in Physics, Biology and Medicine, 1–10.
  • Monograph Fluid electrolyte acid base for students and residents
  • An Integrated Osteopathic-Neurological-Exams with Musculoskeletal Treatment: The “ONE” Approach Charles R. Joseph, MD, Michael D. Lockwood, DO, FCA, FAAO, Michael P. Cargill, OMS-III, Alyssa M. Jackson, OMS-III, Jessica K. Morris, OMS-III (in peer review) Neurology: Clinical Practice February 2022 vol. 12 no. 1 85-90 doi:10.1212/CPJ.0000000000001121
  • Utilizing Timed Categorical Recall (naming U. S. cities) for Rapid Bedside Dementia Screening Charles R Joseph, MD, Michael P Cargill BS, Chansoon D Lee Medicine. 101(31):e29518, August 05, 2022 doi: 10.1097/MD.0000000000029518
  • Novel MRI techniques identifying vascular leak and paravascular flow reduction in early Alzheimer disease Joseph, C. R. (2020, July 1).. Biomedicines, Vol. 8, p. 228.
  • Utilizing 3D Arterial Spin Labeling to Identify Cerebrovascular Leak and Glymphatic Obstruction in Neurodegenerative Disease Joseph, C. R. Diagnostics 2021, 11, 1888.
  • A Review of Fluid Flow in and Around The Brain, Modeling, and Abnormalities (Added) Book Chapter Publisher: Academic Press Date Published: 2021
  • Basics of Fluid, Electrolyte and Acid-Base Disturbances: Treatment Guidelines for Medical Students and Residents 2nd edition Charles R. Joseph, MD chief author, Subhasish Bose, MD, John Sinkovich, DO, Macie Bingham, BS, illustrator. ISBN9798408590117 Kindle 2021