John R. Martin, PhD

Interim Chair, Department of Integrative Physiology and Pharmacology; Professor of Pharmacology

(434) 582-8507

Education

  • PhD, University of Minnesota
  • MS, University of the Pacific
  • BS, University of California

Biography

Dr. Martin’s research interest is in the regulation of the cardiovascular system by specific regions of the brain thought to be involved in the control of blood pressure, particularly the posterior hypothalamic nucleus, the neurotransmitters of this region, and the connections of this nuclei with other brain areas, especially the descending cholinergic projection from the anterior hypothalamic nucleus. These studies include the modifying effect that cannabinoids have on changes in blood pressure evoked by administration of serotonergic, cholinergic or NPYergic agonists into these various regions. In addition, Dr. Martin’s laboratory is also interested in the potential neuroprotective effect of cannabinoids on ischemia and reperfusion following middle cerebral artery occlusion.

Dr. Martin has an interest in innovative teaching methods that engage students in active learning, particularly Team-Based Learning (TBL). He has used TBL for the last ten years as the preferred method for facilitating the learning of pharmacology by students in the health care professions. He has given workshops to faculty on the delivery of course content using TBL, the evaluation of student learning through formative and summative assessments, and the development and use of rubrics.

Courses Taught

  • Integument and Musculoskeletal Systems – IMSK
  • Cardiovascular Respiratory Hematologic System – CVRH
  • Urinary System – URI
  • Gastroenterology – GI
  • Cardio/pulmonology – CP
  • Neurology/Psychiatry/Ophthalmology – NPO
  • Pediatrics – PEDS
  • Orthopedics/Rheumatology/Dermatology – ORD

Professional Memberships

  • American Society for Pharmacology and Experimental Therapeutics
  • Society for Neuroscience
  • Team-Based Learning Collaborative

Publications

  • Andicochea, C.T., A.K Ramsey, J.R. Martin.  Effects of lead-acetate on neurobehavior and learning in the kitten. J Neurol Neurophysiol 9:474-481, 2018, doi 10.4172/2155-9562.1000474
  • Martin, J.R.Pathophysiology, and Pharmacology of Obstructive Pulmonary Disease: Asthma. The Team-Based Learning Collaborative Resource Bank. 18 December 2017, https://www.teambasedlearning.org/tblc-resource-bank/.
  • Newey, C.R. and J.R. Martin. Increase in sensitivity of the baroreceptor reflex following microinjection of carbachol into the posterior hypothalamic nucleus of awake rats.   Autonomic and Autocoid Pharmacology36:3-12, 2016.
  • Martin, J.R.Peptide YY administration into the posterior hypothalamic nucleus of the rat evokes cardiovascular changes by nonadrenergic, noncholinergic mechanisms. Autonomic and Autocoid Pharmacology 25:53-67, 2005.
  • Martin, J.R.The Y1receptor subtype mediates the cardiovascular changes evoked by NPY administration into the posterior hypothalamic area of conscious rat. Brain Res.1002:11-20, 2004.
  • Martin, J.R.Neuropeptide Y potentiates the pressor response evoked by carbachol administration into the posterior hypothalamic nucleus of conscious rat. Brain Res.949:79-87, 2002.
  • Methvin, J.M. and J.R. Martin. Cardiovascular responses evoked by carbachol microinjection into the posterior hypothalamus involves ganglionic nicotinic and muscarinic mechanisms. J. Auton. Pharmacol.18:177-187, 1998.
  • Martin, J.R.DMPP-induced postganglionic sympathetic nerve activity occurs by two mechanisms. J. Auton. Pharmacol. 17:249-259, 1997.
  • Martin, J.R.Pressor effect of the M1muscarinic agonist McN-A-343 occurs by a muscarinic and a nonmuscarinic mechanism.  J. Auton. Pharmacol. 16:281-292, 1996.
  • Martin, J.R.Pressor response to the putative muscarinic M1agonist McN-A-343 in the conscious rat.  Life Sci. 59:1839-1852, 1996.

Research Interests

  • Central control of blood pressure, particularly the role of neurotransmitters, neuropeptides, and endocannabinoids found in specific regions of the hypothalamus and brainstem
  • Effectiveness of Team-Based Learning (TBL)