Office: Micro/Molecular Hall (Dorm 13) 206
Dr. Andrew J. Fabich grew up in a suburb of Cleveland, OH before moving to Columbus, OH to finish high school and attend Ohio State. After finishing his undergraduate degree, he married his high school sweetheart and began graduate school. His first two children were born during graduate school just before he took a teaching job at Tennessee Temple University. While in Chattanooga, his other 2 children were born before joining the faculty at Liberty University in 2011. Dr. Fabich did his dissertation on understanding how good and bad E. coli colonize the mammalian intestine to cause disease. He continues working on molecular pathogenesis and colonization of facultative anaerobes in the mammalian intestine.
The goal of Dr. Fabich's research is to involve undergraduate students to help them better understand the molecular pathogenesis an dissemination of facultative anaerobes in the mouse intestine. They use the streptomycin-treated mouse model of colonization to better understand how commensal (good) E. coli reacts within a diverse intestinal microbial population. The current research focus is investigating how laboratory, human commensal, and probiotic E coli oscillate between motile and non-motile populations in the intestine. The other half of the research group focuses on how pathogenic (bad) E. coli colonize the intestine using the model organism Citrobacter rodentium.
Students at Liberty University work with Dr. Fabich to elucidate the underlying mechanisms that commensal and pathogenic E. coli by genome sequencing of individual E coli clones, 16S rDNA analysis of fecal genomic DNA by quantitative PCR, and metagenomics to identify significant effects from the neighboring bacteria that various E. coli encounter during colonization or pathogenesis. Students also work on understanding the inflammatory process that C. rodentium causes in conventional mice, which is absent in streptomycin-treated mice. We work at better understanding the underlying mechanisms of colonization to aid discovery of novel therapies that enhance commensal E. coli and prevent pathogenic E. coli.
American Society of Microbiology
Virginia Academy of Sciences
Fabich AJ, Leatham MP, Grissom JE, Wile G, Lai H, Najar F, Roe BA, Cohen PS, Conway T. 2011. Genotype and phenotypes of an intestine-adapted Escherichia coli K-12 mutant selected by animal passage for superior colonization. Infect. Immun. 2011 Mar 21. PMCID: PMC3125843
Snider TA, Fabich AJ, Conway T, Clickenbeard KD. 2009. E. coli O157:H7 catabolism of intestinal mucin-derived carbohydrates and colonization. Vet Microbiol. 2009 Apr 14;136(1-2):150-4.
Fabich AJ, Jones SA, Chowdhury FZ, Cernosek A, Anderson A, Smalley D, McHargue JW, Hightower GA, Smith JT, Autieri SM, Leatham MP, Lins JJ, Allen RL, Laux DC, Cohen PS, Conway T. 2008. Comparison of carbon nutrition for pathogenic and commensal Escherichia coli strains in the mouse intestine. Infect. Immun. 76(3):1143-52. PMCID: PMC2258830
Jones SA, Chowhury FZ, Fabich AJ, Anderson A, Schreiner DM, House AL, Autieri SM, Leatham MP, Lins JJ, Jorgensen M, Cohen PS, Conway T. 2007. Respiration of Escherichia coli in the mouse intestine. Infect. Immun. 75(10):4891-9 PMCID: PMC2044527
Snider TA, Fabich AJ, Washburn KD, Sims WP, Blair J, Cohen PS, Conway T, Clickenbeard KD. 2006. Evaluation of a model for Escherichia coli O157:H7 colonization in streptomycin-treated adult cattle Am. J. Vet. Res. 67(11):1914-20.